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reacted to SeaWolf-AI's post with 🔥 about 12 hours ago
3,631 candidate molecules arrived in five days, from 83 accounts — roughly 700 a day. Far more than we expected. Thank you. Yesterday we opened the third season and 224 arrived within a day: Chagas disease. Why this disease Around 6 million people live with it, mostly in Latin America (WHO). Many carry it for decades without knowing, while the heart is slowly damaged. There are two drugs and both date from the 1960s, hard enough to tolerate that many patients cannot finish the two-month course. Sixty years without a new drug is not only a scientific problem. Most patients live where development costs cannot be recovered, which is why WHO calls this a neglected tropical disease. But the cost of proposing a candidate and filtering it has changed. So it seemed worth asking whether work nobody funds could be done by many people sharing it out. The problem this season The target is CYP51, the enzyme T. cruzi uses to build its membrane sterols. Block it and the parasite cannot survive. The difficulty is that we carry the same enzyme. Scoring: binding 30 · selectivity 30 · ADMET 15 · whole-cell 10 · novelty 10 · synthesis 5 Selectivity carries 30 points because nobody has solved it. Among the approved azoles on the board as reference compounds, some score 0 on selectivity — not a scorer fault, but the measurement. Taking part Design with any model, submit a SMILES, scored within minutes. Five ready-to-paste prompts per season, and the full rubric is published. Your molecule stays yours; private submission is the default. Prizes — 4,000 USD across three seasons Malaria 30 Sep · 1,000 | Tuberculosis 31 Oct · 2,000 | Chagas 30 Nov · 1,000 We know this does not cover the time you spend. It is a way of saying the work had worth. https://huggingface.co/spaces/FINAL-Bench/open-discovery-challenge
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